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The awareness of human separation, without reunion by love—is the source of shame. It is at the same time the source of guilt and anxiety.

The deepest need of man, then, is the need to overcome his separateness, to leave the prison of his aloneness. The absolute failure to achieve this aim means insanity, because the panic of complete isolation can be overcome only by such a radical withdrawal from the world outside that the feeling of separation disappears—because the world outside, from which one is separated, has disappeared.

Man—of all ages and cultures—is confronted with the solution of one and the same question: the question of how to overcome separateness, how to achieve union, how to transcend one’s own individual life and find atonement

The Art of Loving, Erich Fromm